Novel Therapeutic Targets in Severe Shock Treatment

Severe or irreversible shock is a final stage of shock, during which the anti-shock treatment including infusion or transfusion, vasoactive agent, cardiotonic drug, etc, is generally ineffective [1,2]. Therefore, it is important to look for a new approach in the treatment of severe shock. After treatment of shock still exist persistent low microcirculatory perfusion, refractory hypotension and cell injury even MODS, which are 3 main factors in the pathogenesis of severe shock (Figure 1). The works in our lab were focused on the 3 genesis factors in the past 50 years [3], during which following therapeutic targets were found in the treatment of severe shock.

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Author: Ke-seng Zhao

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